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探讨接纳与承诺疗法对抑郁症患者负性情绪及应对方式的影响.[方法]选择2015年1月至2017年7月本院收治的抑郁症患者2659例为研究对象,采用随机数表法分为观察组1350例和对照组1309例.两组患者均给予抗抑郁、抗焦虑药物治疗,对照组给予包括健康教育、心理护理、认知干预等在内的常规护理干预,观察组在对照组的基础上联合应用接纳与承诺疗法.随访6个月,采用焦虑自评量表(SAS)、抑郁自评量表(SDS)评价患者焦虑抑郁情况,采用应对方式问卷(CSQ)测评患者负性情绪、应对方式.[结果]观察组患者SAS、SDS评分明显低于对照组(P<0.01);求助、解决问题、合理化评分明显高于对照组,自责、退避、幻想明显低于对照组(P<0.05).[结论]接纳与承诺疗法有助于缓解抑郁症患者焦虑、抑郁情绪,规避消极应对行为,促进积极应对行为方式的养成,值得临床推广应用.“,”Toinvestigatetheeffectofacceptanceandcommitmenttherapyonthenegativee-motionsandcopingstylesofpatientswithdepression.[Methods]Atotalof2659patientswithdepressionfrom January2015toJuly2017wererandomlydividedintotheobservationgroup(n=1350)andthecontrolgroup (n=1309).Patientsinbothgroupsweregivenantidepressantandanti-anxietydrugs.Thecontrolgroupre-ceivedconventionalnursinginterventionsincludinghealtheducation,psychologicalnursingandcognitiveinter-ventions.Theobservationgroupreceivedacceptanceandcommitmenttherapyinadditiontotreatmentsinthe controlgroup.After6 monthsoffollow-up,negativeemotionandcopingstyleswereassessedusingtheSelf-ratingAnxietyScale (SAS),theSelf-rating Depression Scale (SDS)andthe Coping Style Questionnaire (CSQ).[Results]TheSASandSDSscoresintheobservationgroupweresignificantlylowerthanthoseinthe controlgroup (P<0.01).Theabilityofseekinghelp,problemsolvingandrationalizationscoresintheobser-vationgroupweresignificantlyhigherthanthoseinthecontrolgroup (P<0.01);andself-reproach,with-drawal,andillusionweresignificantlylowerthaninthecontrolgroup (P<0.05).[Conclusion]Acceptance andcommitmenttherapycanhelprelieveanxietyanddepression,avoidnegativecopingbehaviors,andpro-motethedevelopmentofpositivecopingbehaviorsinpatientswithdepression.