目的探讨阿魏酸钠联合氯沙坦治疗早期糖尿病肾病的疗效。方法将2009年11月-2012年10月间我院106例早期糖尿病肾病患者随机分为两组各53例,观察组给予阿魏酸钠联合氯沙坦治疗,对照组给予氯沙坦治疗,分析两组疗效。结果观察组SCr、24h尿蛋白定量显著低于对照组,治疗效果显著优于对照组,组间差异有统计学意义(P<0.05)。结论在氯沙坦基础上联合使用阿魏酸钠治疗早期糖尿病肾病的疗效确切,可显著患者肾功能,值得临床应用推广。 Objective To investigate the efficacy of sodium ferulate combined with losartan in the treatment of early diabetic nephropathy. Methods 106 patients with early diabetic nephropathy in our hospital from November 2009 to October 2012 were randomly divided into two groups of 53 patients. The observation group was treated with sodium ferulate combined with losartan and the control group with losartan. Analysis of two groups of curative effect. Results In the observation group, the proteinuria of urinary protein in SCr and 24h was significantly lower than that in the control group, and the therapeutic effect was significantly better than that in the control group. There was significant difference between the two groups (P <0.05). Conclusion The combination of losartan and sodium ferulate in the treatment of early diabetic nephropathy is effective and can significantly affect the renal function of patients. It is worthy of clinical application.