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目的:观察参芪健胃汤对中晚期胃癌患者血管内皮生长因子C(VEGF-C)抑制作用。综合评价以参芪健胃汤配合化疗,对中晚期胃癌患者的血常规、肝功能、免疫功能、肿瘤标志物水平、临床症状及生活质量的改善情况。方法:采用ELISA法定量检测治疗组与对照组治疗前后血清VEGF-C的表达水平,并分析其在治疗后的差异性;综合评价以参芪健胃汤辅助胃癌化疗,患者的血常规、肝功能、免疫功能、肿瘤标志物水平、临床症状及生活质量的改善情况。结果:参芪健胃汤能抑制中晚期胃癌血清VEGF-C的表达水平。结论:参芪健胃汤可通过抗肿瘤血管生成而抑制胃癌生长,并有改善化疗患者的生活质量、临床症状,减轻化疗药物的血液学毒性的疗效。
Objective: To observe the inhibitory effect of Shenqi Jianwei Decoction on vascular endothelial growth factor C (VEGF-C) in patients with advanced gastric cancer. Comprehensive evaluation of Shenqi Jianwei Decoction combined with chemotherapy, to improve the blood routine, liver function, immune function, tumor markers, clinical symptoms and quality of life of patients with advanced gastric cancer. Methods: ELISA was used to quantitatively detect the expression level of serum VEGF-C in the treatment group and the control group before and after treatment, and analyze the difference after treatment. Comprehensive evaluation with Shenqi Jianwei Decoction assisted gastric cancer chemotherapy, the patient’s blood routine, liver Functional, immune function, tumor marker levels, clinical symptoms, and quality of life improvement. Results: Shenqi Jianwei Decoction can inhibit the expression of VEGF-C in middle and advanced gastric cancer. Conclusion: Shenqi Jianwei Decoction can inhibit the growth of gastric cancer by anti-tumor angiogenesis, improve the quality of life and clinical symptoms of chemotherapy patients, and reduce the hematological toxicity of chemotherapy drugs.