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目的 :探讨唾液酸化路易斯 (SLe X)、E 上皮钙粘素 (ED)和p1 6蛋白表达在胆管癌中的意义。方法 :用免疫组化方法 ,检测43例胆管癌组织中SLe X和ED蛋白表达。综合分析了SLe X、ED和p1 6表达与胆管癌临床病理因素间的关系。结果 :在胆管癌组织中 ,SLe X、ED、p1 6表达阳性率分别为 67 4%、53 5 %和 44 2 %。SLe X高表达和ED及p1 6低表达与胆管癌的TNM分期、分化程度和转移密切相关 (P <0 0 5)。SLe X表达与ED和p1 6表达呈负相关 (r=- 0 .45 ,r=- 0 .49,P <0 .0 5)。结论 :检测SLe X、ED和p1 6基因表达可作为预测胆管癌生物学行为和预后的参考指标
Objective: To investigate the significance of SLe X, E-cadherin (ED) and p16 protein expression in cholangiocarcinoma. Methods: The expressions of SLe X and ED in 43 cases of cholangiocarcinoma were detected by immunohistochemistry. The relationship between the expression of SLe X, ED and p16 and the clinicopathological factors of cholangiocarcinoma was analyzed comprehensively. Results: The positive rates of SLe X, ED and p16 in cholangiocarcinoma tissues were 67 4%, 53 5% and 44 2% respectively. High expression of SLe X and low expression of ED and p16 are closely related to TNM staging, differentiation and metastasis of cholangiocarcinoma (P <0.05). The expression of SLe X was negatively correlated with ED and p1 6 expression (r = - 0.45, r = - 0.49, P <0.05). Conclusion: The detection of SLe X, ED and p1 6 gene expression can be used as a reference index to predict the biological behavior and prognosis of cholangiocarcinoma