论文部分内容阅读
目的探讨食管腺癌患者上皮钙黏蛋白(E-cad)和β-连环蛋白(β-cat)表达与临床病理特征及预后关系。方法应用免疫组化方法检测51例食管腺癌组织中E-cad和β-cat的表达,术后对患者进行随访以了解生存情况,结合患者临床病理学特征、生存期进行统计学分析。结果在所有食管腺癌组织标本中,E-cad膜表达与腺癌分化程度、浸润深度、有无淋巴结转移有密切关系(P<0.05);β-cat蛋白异常表达与腺癌低级别分化相关(P<0.05);两种蛋白异常表达率均随临床分期进展而显著增加(P<0.05),E-cad、β-cat表达异常者生存期显著缩短,具有明显的死亡风险(PE=0.01,Pβ<0.001),但E-cad、β-cat并不能作为预测食管腺癌预后的独立因素。结论 E-cad和β-cat表达异常是判断食管腺癌浸润转移的重要指标,能够影响患者预后。
Objective To investigate the relationship between the expression of E-cad and β-catenin in patients with esophageal adenocarcinoma and their clinicopathological features and prognosis. Methods The expressions of E-cad and β-cat in 51 cases of esophageal adenocarcinoma were detected by immunohistochemistry. The patients were followed up for survival after operation, and the clinicopathological characteristics and survival were analyzed statistically. Results The expression of E-cad in all esophageal adenocarcinoma tissues was closely related to the differentiation degree, depth of invasion and lymph node metastasis (P <0.05). The abnormal expression of β-cat protein was associated with the low-grade differentiation of adenocarcinoma (P <0.05). The abnormal expression rate of both proteins increased significantly with the progress of clinical stage (P <0.05). The survival of patients with abnormal expression of E-cad and β-cat was significantly shortened and had a significant risk of death , P <0.001). However, E-cad and β-cat can not be used as predictors of the prognosis of esophageal adenocarcinoma. Conclusions The abnormal expression of E-cad and β-cat is an important index to judge the invasion and metastasis of esophageal adenocarcinoma and can affect the prognosis of patients.