论文部分内容阅读
目的探究肌钙蛋白浓度与严重脓毒症患者预后的关系。方法选取2013年1月—2014年1月玉山县人民医院ICU收治的严重脓毒症患者120例,根据患者入院时血清肌钙蛋白浓度分为肌钙蛋白升高组(肌钙蛋白>1.68μg/L)78例和肌钙蛋白正常组(肌钙蛋白<1.68μg/L)42例,分别比较患者入院24 h、48 h、7 d时血清肌钙蛋白浓度、急性生理学及慢性健康状况评分系统Ⅱ(APACHEⅡ)评分及机械通气率、住院时间、28 d生存率。结果入院24 h、48 h、7 d肌钙蛋白升高组血清肌钙蛋白浓度、APECHEⅡ评分、病死率均高于肌钙蛋白正常组(P<0.05)。两组患者机械通气率比较,差异无统计学意义(P>0.05);肌钙蛋白升高组住院时间长于肌钙蛋白正常组,28 d生存率低于肌钙蛋白正常组(P<0.05)。结论动态监测严重脓毒症患者肌钙蛋白浓度有助于临床医生早期判断病情,其对疾病的预后也有一定的预测价值。
Objective To investigate the relationship between troponin concentration and the prognosis of patients with severe sepsis. Methods One hundred and twenty patients with severe sepsis admitted to ICU of Yushan County People’s Hospital from January 2013 to January 2014 were enrolled. According to the concentration of serum troponin on admission, patients were divided into troponin raising group (troponin> 1.68μg / L) and 42 cases of normal troponin (troponin <1.68μg / L). Serum levels of troponin, acute physiology and chronic health status were compared between 24 h, 48 h and 7 d after admission System Ⅱ (APACHE Ⅱ) score and mechanical ventilation rate, hospital stay, 28 d survival rate. Results Serum troponin concentration, APECHEⅡscore and fatality rate at 24 h, 48 h and 7 d after admission were higher than those in normal troponin group (P <0.05). There was no significant difference in mechanical ventilation between the two groups (P> 0.05). The length of stay in troponin group was longer than that in normal troponin group, and the survival rate at 28 d was lower than that in normal troponin group (P <0.05) . Conclusions The dynamic monitoring of troponin concentration in patients with severe sepsis can help clinicians to judge the disease at an early stage and have certain predictive value for the prognosis of the disease.