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为观察西地那非对精子活动度的影响,Mostafa T进行了一项相关研究。研究者选取85例精子无力症患者的精液标本,评估不同浓度枸橼酸西地那非在体外对于人类精子活动度的作用。每例标本均平均分成6份,其中一份设为对照,其他标本加入用倍比稀释法分成五份不同浓度的西地那非溶液(4.0、2.0、1.0、0.5、0.1mg)。培养所有样本,分别在0.5、1、2、3h检测精子活动力的变化。结果显示,橘橼酸西地那非在体外对于精子活动度有剂量依赖性促进作用。
To observe the effect of sildenafil on sperm motility, Mostafa T conducted a related study. The researchers selected semen samples from 85 patients with sperm dysfunction and evaluated the effects of different concentrations of sildenafil citrate on human sperm motility in vitro. Each sample was equally divided into 6 parts, one of which was set as a control. The other specimens were divided into five different concentrations of sildenafil solution (4.0, 2.0, 1.0, 0.5, 0.1 mg) by multiplying dilution. All samples were cultured, and the changes of sperm motility were detected at 0.5, 1, 2, 3 h respectively. The results showed that sildenafil citrate dose-dependently stimulated sperm motility in vitro.