目的探讨白内障摘除术后周边性角膜水肿—Ｂｒｏｗｎ－ＭｃＬｅａｎ综合征的发病机理。方法对５例（８只眼）患者进行超声角膜厚度测量及角膜内皮显微镜检查，并对其临床表现和发病机理进行分析。结果术后角膜水肿平均发生时间为１０．５年，水肿发生于角膜下方，向上方周边部进展，中央保持透明；水肿区角膜厚度增加，其内皮上可见点状棕色色素性后沉着物，中央区内皮细胞密度减低。结论周边性角膜水肿是一种国内尚未见文献报告的新的角膜水肿类型。其临床表现与白内障摘除术后发生的持续性角膜水肿不同。病因不明，可能与无晶体眼、慢性葡萄膜炎或某些遗传特性有关。 Objective To investigate the pathogenesis of borderline corneal edema-Brown-McLean syndrome after cataract extraction. Methods Ultrasound corneal thickness measurement and corneal endothelial microscopy were performed on 5 patients (8 eyes), and their clinical manifestations and pathogenesis were analyzed. Results The average time of postoperative corneal edema was 10.5 years. Edema occurred below the cornea and progressed to the periphery of the upper part. The cornea remained clear in the edema area. Corneal thickness increased in the edema area. Regional endothelial cell density decreased. Conclusion Peripheral corneal edema is a new type of corneal edema that has not been reported in the literature. Its clinical manifestations and cataract surgery after persistent corneal edema. Etiology is unknown and may be related to aphakia, chronic uveitis or certain genetic characteristics.