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目的:观察黄芪皂苷注射液对实验性心衰犬心脏舒缩功能的影响。方法:采用心得安诱发麻醉犬在体急性心衰模型,静脉注射黄芪皂苷注射液,同时测定左心室收缩压(LVSP)、左室舒张末压(LVEDP)、收缩压最大上升速率(+dp/dtmax)、舒张压最大下降速率(-dp/dtmax)及心率(HR)等指标。结果:黄芪皂苷注射液能明显增加心衰犬LVSP,+dp/dtmax,-dp/dtmax,对LVEDP和(HR)无明显影响。结论:黄芪皂苷注射液可增强心肌收缩力,改善心脏收缩和舒张功能,对急性心衰有明显的治疗作用。
Objective: To observe the effect of astragaloside injection on cardiac systolic and diastolic function in experimental heart failure dogs. Methods: Anesthesia dogs were induced by propranolol and the astragaloside injection was given intravenously. The left ventricular systolic pressure (LVSP), left ventricular end-diastolic pressure (LVEDP) and maximum systolic pressure (+ dp / dtmax, -dp / dtmax and heart rate (HR). Results: Astragaloside injection significantly increased LVSP, + dp / dtmax and -dp / dtmax, but had no significant effect on LVEDP and HR. Conclusion: Astragaloside injection can enhance myocardial contractility, improve cardiac contractility and diastolic function, and have obvious therapeutic effect on acute heart failure.