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组织细胞可经过多种途径产生氧自由基(ROS),而肿瘤组织由于多种应激因素会产生大量ROS,其中最重要的是过氧化氢(H2O2).H2O2对细胞发挥着致损伤及亚毒性信使的双重作用,作为信使其不仅参与调节正常细胞信号通路,重要的是促进肿瘤的发生及进展.ROS作为一种应激刺激信号激活细胞内的AP-1(activator protein 1)、Nrf-2(NF-E2-related factor 2)等核转录因子,活化后的AP-1、Nrf-2会结合到硫氧还蛋白(sulfiredoxin,SRX)基因启动子上游的调控序列,促进SRX基因的表达.SRX的表达上调则影响其下游的抗氧化蛋白,即特定亚型的过氧化物氧还蛋白(peroxiredoxin,PRX)的活性状态,最终使细胞内H2O2浓度受到调节.由SRX-PRX轴与H2O2形成1个环路,通过调节H2O2含量来参与细胞众多信号通路.本文对H2O2、SRX及PRX各自的功能进行综述,还进一步探讨三者构成的信号环路对肿瘤的调控机制,从而了解该环路在肿瘤发生发展中所发挥的作用.
Tissue cells can produce oxygen free radicals (ROS) through a variety of pathways, and tumor tissue due to a variety of stress factors will produce a large number of ROS, the most important of which is hydrogen peroxide (H2O2) .H2O2 exerts damage on cells and Asia The dual role of toxic messengers, messenger not only involved in the regulation of normal cell signaling pathways, it is important to promote tumorigenesis and progression.ROS as a stimulus signal activation of intracellular AP-1 (activator protein 1), Nrf- 2 (NF-E2-related factor 2) and other nuclear transcription factors, the activated AP-1 and Nrf-2 will bind to regulatory sequences upstream of the promoter of sulfiredoxin (SRX) gene and promote the expression of SRX gene The up-regulation of SRX affects the downstream antioxidant protein, the specific subtype of peroxiredoxin (PRX), and finally regulates the concentration of H2O2 in the cells.The SRX-PRX axis and H2O2 Form a loop, by regulating the content of H2O2 to participate in many cell signaling pathways.This paper reviews the respective functions of H2O2, SRX and PRX, and further explores the regulatory mechanism of the three signal loops on the tumor, so as to understand the loop Road in the tumor Health development in the role.