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目的比较奥美拉唑与雷尼替丁治疗非甾体类抗炎药相关性胃溃疡的临床疗效。方法选取2011年7月~2012年7月于江西省新干县大洋洲镇中心卫生院经胃镜确诊为非甾体类抗炎药(NSAIDs)相关性胃溃疡患者60例。所有患者均维持原非甾体类抗炎药的临床治疗。根据就诊前后随机分为2组,治疗组30例口服奥美拉唑20 mg,1次/d;对照组30例口服雷尼替丁150 mg,2次/d。2组患者用药3个月后对比胃镜下粘膜损伤恢复情况及上消化道症状的发生情况。结果 2组经3个月治疗后,治疗组中11例粘膜充血、2例糜烂,无1例溃疡,余患者粘膜恢复正常。对照组18例粘膜充血、4例糜烂、1例溃疡。2组经χ2检验,差异具有统计学意义(P<0.05)。治疗组消化道症状发生率为16.7%,明显低于对照组33.3%,2组比较,差异具有统计学意义(P<0.05)。结论在治疗非甾体类抗炎药相关性胃溃疡上,奥美拉唑的临床疗效明显优于雷尼替丁,临床上值得进一步研究应用。
Objective To compare the clinical efficacy of omeprazole and ranitidine in the treatment of nonsteroidal anti-inflammatory drug-related gastric ulcer. Methods Sixty patients with gastric ulcer associated with non-steroidal anti-inflammatory drugs (NSAIDs) diagnosed by gastroscope from July 2011 to July 2012 in Central Health Center of Oceania Town, Xingan County, Jiangxi Province were selected. All patients maintained the original non-steroidal anti-inflammatory drugs for clinical treatment. According to the pre-treatment and post-treatment, patients were randomly divided into 2 groups: 30 patients in the treatment group were given omeprazole 20 mg once daily, and 30 patients in the control group were given ranitidine 150 mg twice daily. Two groups of patients after 3 months of medication compared with gastroscopic mucosal damage recovery and the occurrence of upper gastrointestinal symptoms. Results After 3 months of treatment, 11 cases of mucosal hyperemia and 2 cases of erosion in the treatment group had no ulcer, and the mucosa of the rest patients returned to normal. Control group, 18 cases of mucosal congestion, 4 cases of erosion, 1 case of ulcer. Two groups by χ2 test, the difference was statistically significant (P <0.05). The incidence of gastrointestinal symptoms in the treatment group was 16.7%, which was significantly lower than that in the control group (33.3%). There was significant difference between the two groups (P <0.05). Conclusion The clinical efficacy of omeprazole is better than that of ranitidine in the treatment of non-steroidal anti-inflammatory drug-related gastric ulcer, which is worth further study and application.