他汀药主要用于调降血脂,兼有抗炎等效用。然而关于其对结缔组织病(CTD)罹患风险的效用远不清楚,现就其进行大样本对照分析。受测对象为46 488例观察个体,均于2003年10月~2005年9月纳入研究,基线年龄30~85岁。研究中分为随机首次服用他汀药至少90 d的治疗组13 640例,或素未使用他汀药的对照组32 848例。且基线均素无CTD。在治疗组人均用药(1 694±663)d。尔后人均用药或随访约5年,最后仅将其中 Statins are mainly used to lower blood lipids, both anti-inflammatory and other effects. However, its utility for the risk of connective tissue disease (CTD) is far from clear and large-scale, controlled trials are now underway. Subjects were 46 488 observed individuals, all from October 2003 to September 2005 included in the study, the baseline age of 30 to 85 years. The study included 13,640 patients in the treatment group who were randomized to first receive statins for at least 90 days, or 32,848 patients in the control group who did not use statins. And baseline no CTD. The treatment group per capita medication (1 694 ± 663) d. After per capita drug use or follow-up of about 5 years, and finally only among them