多系统变性病是一组原因不明的神经系统多部位萎缩性疾病,包括原发性直立性低血压、橄榄桥小脑萎缩、帕金森—痴呆综合征、纹状体黑质变性和进行性核上性麻痹等,临床上较少见。我们曾收治过5例原发性直立性低血压(例1—5)、2例橄榄桥小脑萎缩(例6.7)、1例帕金森—痴呆综合征(例8),报告如下。各病例的临床表现与体征、治疗药物与疗效见附表。 8例中有5例行腰穿检查,脑压、脑脊液常规 Multi-system degenerative disease is a group of unexplained multi-location atrophic diseases of the nervous system including primary orthostatic hypotension, olivopontocerebellar atrophy, Parkinson’s-dementia syndrome, striatonigral degeneration and progressive nuclear Sexual paralysis, clinically rare. We have received 5 cases of primary orthostatic hypotension (cases 1-5), 2 cases of olive tree cerebellar atrophy (case 6.7), and 1 case of Parkinson’s dementia syndrome (case 8), the report is as follows. The clinical manifestations and signs of each case, the treatment of drugs and the efficacy of Schedule. Five of the 8 patients underwent lumbar puncture, and their brain pressure and cerebrospinal fluid were routinely measured