首先分别制备含亲水性药物(二甲双胍)的水溶液和含疏水性药物(格列吡嗪)、脂质的有机溶剂溶液,再利用一种可延展的微流体制造设备分别制备含单一药物,或者内层为亲水性药物、外层为疏水性药物的双层包埋脂质体。试验表明,操作参数、溶剂种类、脂质浓度和水溶液∶溶剂比例都会影响脂质体的粒径,本试验中制品的粒径范围为90~300 nm。无论 First, an aqueous solution containing a hydrophilic drug (metformin) and an organic solvent solution containing a hydrophobic drug (glipizide) and a lipid, respectively, are prepared separately, and then a single drug is separately prepared using a malleable microfluidic manufacturing device or The inner layer is a hydrophilic drug, the outer layer is a hydrophobic drug double-layer embedded liposomes. Experiments show that the operating parameters, solvent type, lipid concentration and aqueous solution: solvent ratio will affect the size of the liposomes, the size of the test particle size range of 90 ~ 300 nm. regardless