本研究以三只狗的２０只前磨牙和磨牙以同一条狗左右侧为实验组和对照组，人工行髓室底穿孔，分别用羟基磷灰石和氢氧化钙行穿通髓室底修补，在一周、一月和两个月作组织学观察，２个月时，两组修补区均在炎症浸润下方有纤维肉芽组织生成和上皮增生，但羟基磷灰石组炎症反应较氢氧化钙组轻。 In this study, 20 premolar teeth and molars of three dogs were used as the experimental group and the control group on the left and right sides of the same dog. The perforation of the medullary cavity was performed manually, and hydroxyapatite and calcium hydroxide Histological observation was performed in one week, one month and two months. At 2 months, there was fibrous granulation tissue formation and epithelial hyperplasia in the inflamed area in both groups, but the reaction of hydroxyapatite group was more severe than that of calcium hydroxide group light.