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目的：动态研究金黄地鼠舌癌发生、发展过程中血管生成的变化规律。方法：采用组织学定量方法，结果：舌部癌前阶段即有血管生成现象，从癌前病变、原位癌、浸润癌发展的不同时期，血管生成现象持续存在，并随着癌细胞的增殖、浸润更为明显，血管增生主要由周边向中心呈向心性增生，肿瘤发展至一定阶段肿瘤中心出现血管生长的停滞。结论：血管生成是舌癌生长、发展的重要先决条件。
Objective: To study the dynamic changes of angiogenesis in the occurrence and development of golden tongue hamster tongue cancer. Methods: Quantitative histological methods were used. Results: There was angiogenesis in the precancer stage of the tongue. From the precancerous lesion, carcinoma in situ, and invasive carcinoma at different stages of development, angiogenesis persisted and along with the proliferation of cancer cells. Infiltration is more obvious, vascular proliferation is mainly from the peripheral to the center of the heart hyperplasia, tumor development to a certain stage of the tumor center appears to stop the growth of blood vessels. Conclusion: Angiogenesis is an important prerequisite for the growth and development of tongue cancer.