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目的:评价血清降钙素原(procalcitonin,PCT)在儿科感染中的实验诊断意义。方法:对212例患儿按临床诊断把患儿分成细菌感染和非细菌感染2组,进行白细胞(WBC)计数、C反应蛋白(CRP)、血清降钙素原(PCT)检测、PCT采用免疫层析法测定,CRP采用免疫层析法,WBC计数采用迈瑞BC5380血球计数仪测定。结果:细菌感染纽与非细菌感染组的PCT、CRP及WBC检测值均高于对照组,差异有统计学意义(P<0.05)。细菌感染组的PCT及WBC检测值均高于非细菌感染组间,差异有统计学意义(P<0.05),而细菌感染组的CRP检测值与非细菌感染组比较差异无统计学意义(P>0.05)。细菌感染组中PCT阳性率(98/118)明显高于非细菌感染组(12/94),差异有统计学意义(P<0.05)。结论:PCT检测能客观评估儿科感染的严重程度及治疗效果,对临床合理应用抗菌素有指导价值。
Objective: To evaluate the significance of procalcitonin (PCT) in pediatric infection. Methods: Two hundred and twelve children were divided into two groups: bacterial infection and non-bacterial infection. The WBC count, C-reactive protein (CRP) and serum procalcitonin (PCT) Chromatography, CRP using immunochromatography, WBC count using Mindray BC5380 blood cell count. Results: The values of PCT, CRP and WBC in bacterial infection group were higher than those in control group (P <0.05). The detection value of PCT and WBC in bacterial infection group was higher than that in non-bacterial infection group, the difference was statistically significant (P <0.05), while there was no significant difference between bacterial infection group and non-bacterial infection group (P > 0.05). The positive rate of PCT in bacterial infection group (98/118) was significantly higher than that in non-bacterial infection group (12/94), the difference was statistically significant (P <0.05). Conclusion: The PCT test can objectively assess the severity of pediatric infection and the therapeutic effect, which is of guiding value to the rational use of antibiotics in clinical practice.