论文部分内容阅读
目的:分析遗传和环境因素分别对于男性吸烟行为和开始吸烟年龄的影响。方法:回顾性调查1006对18岁及以上成年双生子的吸烟状况及开始吸烟年龄,在分析同卵和异卵双生子同吸烟率的基础上分别计算吸烟行为和开始吸烟年龄的遗传度。结果:与西方文化不同,该双生子人群中男性吸烟比例达66.8%,相比之下女性仅有0.2%。同卵双生子中,88.7%(566/638对)的双生子对中两个成员都是吸烟者或者具有吸烟经历或均不吸烟,而异卵双生子此比例仅为63.6%(234/368对)。该双生子样本吸烟行为的遗传度为69.0%±4.1%。双生子平均开始吸烟年龄(20.4±5.3)岁,同卵双生子开始吸烟年龄相关系数0.393,而异卵双生子达0.860。结论:中等程度的遗传度显示遗传因素对于男性双生子选择是否吸烟具有一定的影响,但是什么时候开始吸烟,更多取决于个人环境的影响。
OBJECTIVE: To analyze the effects of genetic and environmental factors on male smoking behavior and the age of onset of smoking respectively. Methods: A retrospective survey of smoking prevalence and smoking age of 1006 pairs of twins aged 18 years and older was conducted. The smoking prevalence and smoking age were calculated based on the same smoking rate of identical and fraternal twins. Results: Unlike Western cultures, 66.8% of men smoked in this twins group compared with only 0.2% of women. Of the identical twins, 88.7% (566/638 pairs) of twins were both smokers or had smoking experience or no smoking, while the proportion of fraternal twins was only 63.6% (234/368 Correct). The heritability of the twins smoking behavior was 69.0% ± 4.1%. The twins averaged the age of smoking (20.4 ± 5.3) years old, and the identical twins had an age-related coefficient of 0.393, while the fraternal twins had 0.860. CONCLUSIONS: Moderately heritability suggests that genetic factors have some influence on whether male twins choose to smoke or not, but when to begin smoking is more dependent on the personal environment.