本发明涉及一种制备非天然氨基酸及其手性拆分的方法,本法以金刚烷甲酸为原料,制备3-羟基金刚烷甲酸,再经过氯化、氧化等得到2-(3-羟基-1-金刚烷基)乙醛酸,与盐酸羟胺反应得到3-羟基金刚烷乙醛酸肟,用还原剂还原并用Boc酸酐保护得到N-叔丁氧羰基-3-羟基金刚烷基甘氨酸。再 The present invention relates to a method for preparing unnatural amino acids and their chiral resolution. In the method, adamantanecarboxylic acid is used as a raw material to prepare 3-hydroxyadamantanecarboxylic acid, which is chlorinated and oxidized to obtain 2- (3-hydroxy- Adamantyl) glyoxylic acid is reacted with hydroxylamine hydrochloride to give 3-hydroxyadamantane glyoxal oxime, which is reduced with a reducing agent and protected with Boc anhydride to give N-tert-butoxycarbonyl-3-hydroxyadamantylglycine. again