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目的探讨宫颈特殊染色法(FRD)上皮组织染色技术用于宫颈癌前病变检测的临床价值。方法选取2014年10月-2015年10月在英德市人民医院就诊的2 627例患者进行检查,所有患者均接受宫颈口及宫颈管同时染色(FRD)、宫颈液基细胞学检查(TCT)及人乳头瘤病毒(HPV)检测,3者任一项提示异常者行阴道镜检查,以阴道镜取材、组织病理学结果为诊断标准。结果以病理诊断CINⅡ阳性为阳性标准,FRD上皮组织染色液的敏感性为97.50%,特异性为14.58%,阳性预测值为32.23%,阴性预测值为93.33%,诊断符合率为38.97%;TCT检查的敏感性为40.00%,特异性为91.67%,阳性预测值为66.67%,阴性预测值为78.57%,诊断符合率为76.47%;HPV检查的敏感性为81.25%,特异性为47.40%,阳性预测值为39.16%,阴性预测值为85.85%,诊断符合率为57.35%。结论作为较为敏感、简便、快速、经济的检测技术,FRD上皮组织染色技术对宫颈癌及癌前病变的检测有重要的临床意义,是宫颈病变的重要临床评估标准。
Objective To investigate the clinical value of cervical special staining (FRD) epithelial tissue staining in the detection of cervical precancerous lesions. Methods Totally 2 627 patients who were treated in Yingde People ’s Hospital from October 2014 to October 2015 were examined. All patients underwent cervical and cervical canal simultaneous staining (FRD), cervical liquid - based cytology (TCT) And human papillomavirus (HPV) test, any one of the three abnormalities were colposcopy, colposcopy drawn, histopathological findings as diagnostic criteria. Results The pathologic diagnosis of CINⅡpositive was positive. The sensitivity, specificity and accuracy of the staining of FRD epithelial tissue were 97.50%, 14.58%, 32.23%, 93.33%, respectively. The diagnostic coincidence rate was 38.97% The sensitivity, specificity and accuracy were 40.00%, 91.67%, 66.67%, 78.57%, 76.47%, respectively. The sensitivity and specificity of HPV testing were 81.25% and 47.40% The positive predictive value was 39.16%, the negative predictive value was 85.85%, and the diagnostic coincidence rate was 57.35%. Conclusion As a sensitive, simple, rapid and economical detection technique, FRD epithelial tissue staining has important clinical significance for the detection of cervical cancer and precancerous lesions, and is an important clinical evaluation criterion for cervical lesions.