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[目的 ]实验观察三乙醇胺染毒大鼠血清脂质过氧化代谢产物 (MDA)含量 ,超氧化歧化酶 (SOD)和全血谷胱甘肽氧化酶 (GSH PX)的活性及组织病理学改变。 [方法 ] 32只大鼠分别经染毒不同剂量的三乙醇胺 (2 5 0、5 0 0、75 0mg/kg) ,每周 1次 ,7周后断头取血检测酶学指标 ,同时进行大体剖检和组织病理学检查。[结果 ]染毒大鼠血清MDA含量明显增高 ,SOD和全血GSH PX活性明显降低 ,与对照组比较差异均有统计学意义 (P <0 0 1) ;5 0 0mg/kg、75 0mg/kg染毒组脏器系数增大 ,肝、脾、肾器官有不同程度的病理学改变。 [结论 ]接触一定量的三乙醇胺可增强染毒大鼠脂质过氧化水平 ,对染毒大鼠肝、脾、肾脏组织有损伤作用
[Objective] To investigate the changes of serum lipid peroxidation metabolites (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GSH PX) and the histopathological changes in rats treated with triethanolamine . [Methods] Thirty-two rats were treated with different doses of triethanolamine (250, 0 0, 0 75, 0 mg / kg) once a week for 7 weeks. General anatomy and histopathological examination. [Result] The content of MDA in serum increased obviously, the activity of GSH PX in SOD and whole blood decreased significantly, the difference was statistically significant compared with the control group (P <0.01) kg, the coefficient of organ increased, and pathological changes of liver, spleen and kidney were observed. [Conclusion] Exposure to a certain amount of triethanolamine can enhance the level of lipid peroxidation in rats, and impair the liver, spleen and kidney of the rats