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钙通道阻滞剂被广泛用于治疗脑血管疾病,对因血管痉挛伴血管基底紧张度失调的疗效最好。本文旨在研究钙通道阻滞剂影响下的大脑各区血管血流量及反应性的变化。给12只大脑插有电极的苏醒家兔注射0.01～0.06mg/kg尼莫地平和0.03～1mg/kg维拉帕米,用氢廓清法做实验,结果如下。首先是血流量的变化。在注射尼莫地平和维拉帕米的最初15～30min内,受检部位大脑组织内局部血流量明显增多,随后便减少。尼莫地平的最佳有效量为0.06mg/kg,其最大血管舒张作用表现在脑皮层血管上,那里的
Calcium channel blockers are widely used in the treatment of cerebrovascular disease, the best effect on vascular spasm with vascular basement disorders. This article aims to study the effects of calcium channel blockers on changes in blood flow and reactivity of blood vessels in various regions of the brain. Twelve awake rabbits with electrodes inserted into the brain were injected with nimodipine 0.01 ~ 0.06mg / kg and verapamil 0.03 ~ 1mg / kg, and the experiment was performed by the hydrogen clearance method. The results are as follows. The first is the change in blood flow. During the first 15 to 30 min of injection of nimodipine and verapamil, local blood flow in the brain tissue of the examined site increased significantly, and then decreased. The best effective dose of nimodipine is 0.06 mg / kg, and its maximal vasodilating effect is on the cortical vessels, where