为了探索新的脑示踪剂,并研究示踪剂在生物体内分布、吸收和代谢,我们进行了麻醉药物~(11)C-Ketamine的合成研究,其合成步骤如下: 邻-氯苯基环己基酮(b_(0.3)96-7℃,n_D~(20) 1.5452)(21g;0.1mol)和溴水(10g,0.625mol)在80ml四氯化碳中,给出1-溴环戊基,邻-氯苯基酮(Ⅰ),化合物(Ⅰ)在过量液氨中进行反应, In order to explore new brain tracer and to study the distribution, absorption and metabolism of tracer in organism, we have carried out the synthesis of ~ (11) C-Ketamine, an anesthetic drug. The synthetic procedure is as follows: o-chlorophenyl ring Hexyl ketone (b_ (0.3) 96-7 ° C, n_D ~ (20) 1.5452) (21 g; 0.1 mol) and bromine water (10 g, 0.625 mol) in 80 ml of carbon tetrachloride gave 1-bromocyclopentyl , O-chlorophenyl ketone (I), the compound (I) is reacted in excess liquid ammonia,