目的 探讨盐酸右美托咪定和咪达唑仑在ICU患者机械通气中的镇静效果评价。方法 将签署知情同意书的56例2018年8月至2019年8月入院患者随机分组，两组患者落实相关镇静措施，使用咪达唑仑治疗的患者为对照组，使用右美托咪定和咪达唑仑镇静治疗的患者为研究组。研究对比两组患者镇静效果。结果 采用不同的药物镇静后，研究组患者的VAS评分、Ramsay评分均低于对照组（P＜0.05）；研究组患者用药后达到理想镇静时间、停药后完全苏醒时间、住院时间均短于对照组（P＜0.05）；研究组患者的不良反应发生率低于对照组（“,”Objective To evaluate the sedative effect of dexmedetomidine hydrochloride and midazolam on mechanical ventilation in ICU patients.Method Fifty-six patients who signed informed consent and were admitted to the hospital from August 2018 to August 2019 were randomly divided into two groups.The patients in the two groups implemented relevant sedation measures.The patients treated with midazolam were the control group，and the patients treated with dexmedetomidine and midazolam were the study group.The sedative effects of the two groups of patients were compared.Results After using different drugs for sedation，the VAS score and Ramsay score of the patients in the study group were lower than those in the control group(P＜0.05).The time to achieve ideal sedation，complete recovery time after drug withdrawal，and hospitalization time in the study group were shorter than those in the control group(P＜0.05).The incidence of adverse reactions in the study group was lower than that in the control group(P＜0.05).The SBP，DBP and HR values at T1 and T2 in both groups were significantly lower than those at T0 after admission(P＜0.05);the SBP，DBP and HR of the control group at T2 were significantly lower than those of the study group(P＜0.05)，with statistical significance.Conclusion Dexmedetomidine hydrochloride and midazolam are used for sedation in mechanical ventilation of ICU patients.The sedation effect is relatively significant，the pain degree of patients is reduced，and the overall prognosis effect is improved，which is worthy of promotion.