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在过去的二十多年里,很少有疾病像乳腺癌一样获得如此多的研究进展,特别是近年来,单细胞研究技术不断进步,掀起了肿瘤异质性研究的热潮。2012年,Gerlinger等[1]的研究有力证实了肿瘤异质性的存在,随后,肿瘤异质性问题越来越多地被提及。对于临床医师而言,肿瘤异质性对临床工作和转化研究有哪些影响,本文将就此回顾最新进展,分享个人观点。1肿瘤异质性1.1异质性的范围肿瘤异质性是一个宽泛的定义,可粗略地分为
In the past 20 years or so, few have gotten so much research progress like breast cancer. Especially in recent years, the continuous improvement of single-cell research has set off a wave of research on tumor heterogeneity. In 2012, the study of Gerlinger et al [1] strongly confirmed the existence of tumor heterogeneity. Subsequently, the issue of tumor heterogeneity was more and more mentioned. For clinicians, what are the implications of tumor heterogeneity for clinical work and translation studies, and this article will review recent developments and share personal perspectives. 1 Tumor Heterogeneity 1.1 The Range of Heterogeneity Tumor heterogeneity is a broad definition that can be roughly divided into