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目的:考察米诺环素对224株肠球菌的体外抗茵活性。方法:用二倍琼脂稀释法对224株肠球菌进行体外抗菌实验,并与多西环素、替考拉宁、万古霉素等进行抗菌效果对比。结果:米诺环素对169株粪肠球菌和51株屎肠球菌的MIC90分别为4和2μg·ml-1,而多西环素对169株粪肠球菌和51株屎肠球菌的MIC90则分别为4和4μg·ml-1。结论:米诺环素对肠球菌的抗菌效果与多西环素相似。
Objective: To investigate the in vitro antimicrobial activity of minocycline against 224 enterococci. Methods: In vitro antibacterial experiment of 224 enterococci with two-fold agar dilution method was carried out and compared with that of doxycycline, teicoplanin and vancomycin. RESULTS: MIC90 of minocycline against Enterococcus faecalis and Enterococcus faecium were 51 and 4 respectively, and MIC90 of doxycycline against 169 Enterococcus faecalis and Enterococcus faecium were 51 4 and 4 μg · ml-1, respectively. Conclusion: The antibacterial effect of minocycline on enterococci is similar to that of doxycycline.