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【目的】探讨严重功能性便秘的相关危险因素。【方法】回顾性分析2009年12月至2014年1月86例本院诊断为功能性便秘患者的临床资料，根据其严重程度分为重度组与非重度组，同时随机选取本院同期体检健康的100例无便秘病史的健康人群作为对照组，筛选出影响严重功能性便秘的相关因素，应用lo‐gistic回归进行多因素回归分析。【结果】重度组患者23例，占26．7％，非重度组患者63例，占73．3％。单因素分析显示：重度组患者病史年限、体质量指数（BM I ）、吸烟史、滥用容积性泻药、抑郁自评量表（SDS ）评分、焦虑自评量表（SAS）评分、肛管缩榨压、肛管排便压均高于非重度患者与对照组，差异有统计学意义（ P ＜0．05）；非重度患者BMI、滥用容积性泻药、SDS评分、SAS评分、肛管缩榨压、肛管排便压均高于对照组，差异有统计学意义（ P ＜0．05）。多因素分析显示滥用容积性泻药、SDS评分、SAS评分、肛管缩榨压、肛管排便压是严重功能性便秘发生的独立危险因素。【结论】严重功能性便秘与长期滥用容积性泻药，焦虑、抑郁等不良情绪及肛门直肠动力学异常密切相关。“,”[Objective] To explore the related factors of functional constipation .[Methods] A total of 86 cases diagnosed as functional constipation as case group .According to severity ,they were divided into severe ( n=23) and non‐severe ( n=63) groups .And another 100 randomly selected healthy persons without a histo‐ry of constipation were selected as control group .The related factors of severe functional constipation were screened and logistic regression analyses performed .[Results]Univariate analyses showed that a history of se‐vere disease ,body mass index (BMI) ,smoking ,long‐term abuse of volumetric laxatives ,self‐rating depres‐sion score (SDS) ,self‐rating anxiety score (SAS) ,anal squeeze pressure and anal defecation pressure were higher than non‐severe patients and controls .And the differences were statistically significant ( P <0 .05) . BMI in non‐severe patients ,long‐term abuse of volumetric laxatives ,SDS score ,SAS score ,anal squeeze pressure and anal defecation pressure were higher than controls .And the differences were statistically signifi‐cant ( P <0 .05) .Further multivariate analyses indicated that long‐term abuse of volumetric laxatives ,SDS score ,SAS score ,anal squeeze pressure and anal defecation pressure were independent risk factors for the oc‐currence of severe functional constipation .[Conclusion] Severe functional constipation are closely correlated with long‐term abuse of volumetric laxatives ,anxiety ,depression ,other negative emotions and abnormal ano‐rectal dynamics .