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目的研究双环醇片治疗慢性乙型肝炎(CHB)在肝组织学方面的变化。方法随机选择31例CHB患者分两组接受治疗,每日口服双环醇片,剂量分别为150和75mg,连续用药36周,观察治疗前后肝组织学的变化。结果治疗36周后,治疗组与对照组肝组织病变活动性积分均有下降,分别为P<0.01和P<0.05,且组间相比差异有统计学意义(P<0.05);肝组织炎症分级下降(P<0.05)。结论双环醇片150与75mg/d治疗CHB均可在明显降低ALT的同时使肝组织学得到明显改善,150mg/d疗效好于75mg/d疗效。
Objective To study the histological changes of chronic hepatitis B (CHB) treated with bicyclol tablets. Methods A total of 31 CHB patients were randomly divided into two groups. Patients were treated with bicyclol tablets daily at doses of 150 and 75 mg for 36 weeks. The changes of liver histology before and after treatment were observed. Results After 36 weeks of treatment, the activity scores of liver lesions in treatment group and control group were decreased, P <0.01 and P <0.05, respectively, and the differences between the two groups were statistically significant (P <0.05); liver inflammation Graded decline (P <0.05). Conclusion Bicyclic alcohol tablets 150 and 75 mg / d treatment of CHB can significantly reduce the ALT while liver histology improved significantly, 150 mg / d better than 75 mg / d effect.