脓毒症是目前世界范围内威胁人类健康的主要问题之一，有着极高的发病率和死亡率。微量营养素(微量元素和维生素)在代谢过程中作为酶的必需成分或辅助因子，发挥着调节免疫和抗氧化作用，在脓毒症发生发展过程中起着重要作用。本文就微量元素(锌、硒、铜)和维生素(维生素C、维生素Bn 1)在脓毒症发生机制中的作用及补充之后对死亡率的影响进行研究。目前，微量营养素的补充能否改变脓毒症的最终死亡率仍存在争议，需要更多的临床试验去验证。n “,”Sepsis is one of the major threats to human health worldwide, with high morbidity and mortality. Micronutrients (microelements and vitamins) play an important role in the occurrence and development of sepsis as essential components or auxiliary factors of enzymes in the process of metabolism. In this paper, the role of trace elements (zinc, selenium, copper) and vitamins (vitamin C, vitamin B1) in the mechanism of sepsis and the effect of supplementation on mortality were studied. At present, whether the supplementation of micronutrients can change the final mortality of sepsis remains controversial and requires more clinical trials to verify.