尖锐湿疣为常见性病,它是由人乳头瘤病毒(HPV)感染所致,其中HPV6、11、16、18是引起尖锐湿疣的最常见亚型.其临床表现为乳头瘤样增......

糖基化神经酰胺合成酶(glucoceramide synthase,GCS)是调控神经酰胺代谢的关键酶之一,其活性增高可能是引起肿瘤获得性多药耐药产......

目的:探讨P-糖蛋白(P-glycoprotein,P-gp)、DNA拓扑异构酶Ⅱα(topoisomeraseⅡα,ToPoⅡα)、谷胱甘肽-S-转移酶(glutathione-S-t......

DNA拓扑异构酶(DNA topoisomerase,Topo)是细胞凋亡过程中关键的核内酶,Topo抑制剂通过作用于Topo抑制肿瘤的活性。然而在临床中,......

Disinfection by-products occur widely as the unintended effect of water disinfection and are associated with toxicity an......

目的:分析基底细胞样型乳腺癌(BLBC)癌灶组织中拓扑异构酶α(TOPOIIα)的表达及意义。方法:88例BLBC导管浸润癌患者作为观察组,同......

A method of screening assay is demonstrated. The approach is based on the affinity ofantitumor candidates for topoisomer......