Background: Clinically, hepatitis B virus (HBV) infection is observed to be associated with nephropathy.Comorbidities or antiviral treatment might further increase renal risk, therefore regular monitoring of renal function is recommended.The well established formulae using serum creatinine for the calculation of glomerular filtration rate(eGFR) are validated only for patients with substantially impaired renal function and not for monitoring patients with normal renal function.There is limited data of early renal injury evaluated in patients with chronic hepatitis B virus infection.Methods: This was a multicentre retrospective observational study conducted in 2 hospitals located at Tianjin China, over a time period between April 2012 and June 2013.The study included 90 patients with chronic hepatitis B virus infection.who never receive antiviral treatment.Based on the hepatitis status,they were divided into three groups named of chronic hepatitis, liver cirrhosis and hepatic carcinoma.Patients were assessed for early renal injury by urinary albumin, urine transferrin, urine IgG, and serum β2 microglobulin, and the informations of patients were also be collected for diagnosis, serum creatinine, eGFR and other laboratory datas.According to clinical characteristics the differences were compared among the three groups of various lab results of patients.Moreover, Logistical regression analysis was conducted to determine the association between early renal injury and the following variables: age, gender, comorbidities (diabetes and hypertension), and chronic disease stages.Results: Creatinine levels in all subjects were in normal range, but the abnormal rate of albumin, transferrin, IgG in urine, or serum β2 microglobulin is much higher than that of eGFR (72.2%VS12.7% X2=56.25, P=0.000).The proportion of early renal injury is different in different status of chronic hepatitis B virus infection.Among those lab results, urinary transferrin levels in patients with chronic hepatitis, cirrhosis and liver cancer were 1.91 ± 1.06mg/L、 2.66 ± 3.01 mg/L、 6.73 ± 8.32 mg/L (X2=7.671, P=0.001) respectively; abnormal rate of urine IgG were 4/30 (13.3%), 15/29 (51.7%), 11/30 (36.7%), F=10.39, P=0.006 ; and the abnormal cases of blood β2 microglobulin were 10/30 (33.3%), 18/29 (62%), 23/30 (76.7%), F=12.75, P=0.00 in three groups respectively.By Lgistical regression analysis, the patients age and disease status are independent risk factors accompany with early renal function abnormalities in patients with chronic HBV infection.Conclusions: There is very high proportion of early renal injury in patients with Hepatitis B virus infection rather than eGFR.Age and disease status are the main factors affecting such abnormalities.It is necessary to assesse early renal injury before the drug selection of antiviral treatment.