Discovery and Structure-Activity Relationship Analysis of 4-((5-nitropyrimidin-4-yl)amino)benzimidam

来源 :2015年全国药物化学学术会议暨第五届中英药物化学学术会议 | 被引量 : 0次 | 上传用户：powermill1

【摘要】

：

【作者】

：

Xu-Ri Yu Yun Tang Wen-Jing Wang Sen Ji Lei Zhong Chun-Hui Zhang Jiao Yang Xiao-Ai Wu Sheng-Yong Yang Lin-Li Li

【机构】

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State Key Laboratory of Biotherapy and Cancer Center,West China Hospital,West China Medical School,S

【出处】

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2015年全国药物化学学术会议暨第五届中英药物化学学术会议

【发表日期】

：

2015年3期

【关键词】

：

PRMT1 small molecule inhibitor epigenetics structure-activity relationship prote

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　　Protein arginine methyltransferase 1(PRMT1)is an important member of PRMT subfamily,which catalyzes the transfer of a methyl group from the co-factor S-adenosyl methionine(SAM)onto a specific arginine residue of its substrate proteins.1-3 Despite a potential application of PRMT1 inhibitors in cancer treatment,very few of PRMT1 inhibitors have been reported.

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Discovery and Structure-Activity Relationship Analysis of 4-((5-nitropyrimidin-4-yl)amino)benzimidam

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