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  5. Study on metabolic pattern of plasma amino acids in rat models with adenovirus infections by gas chr

Study on metabolic pattern of plasma amino acids in rat models with adenovirus infections by gas chr

来源 :DaLian Internationall Symposia and Exhibition on Chromatogra | 被引量 : 0次 | 上传用户：tobenumberone123
【摘 要】
：
The alteration of amino acid (AA) levels in biological fluids including cells associated with viral infectivity.Therefore, AA levels were monitored in rat plasma after the injection with adenovirus, β
【作 者】
：
Moon  S.-M Lee  J Kim.K.-R Ahn  Y.-H Lee  G Paik  M.-J 
【机 构】
：
Institute for Neuroregeneration and Stem Cell Research, Ajou University School of Medicine, Wonchon-
【出 处】
：
DaLian Internationall Symposia and Exhibition on Chromatogra
【发表日期】
：
2007年12期
【关键词】
：
Adenovirus infection Amino acid Gas chromatography-mass spectrometry Star symbol 
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　　The alteration of amino acid (AA) levels in biological fluids including cells associated with viral infectivity.Therefore, AA levels were monitored in rat plasma after the injection with adenovirus, β-galactosidase expressing recombinant adenovirus (designated rAdLacZ) and RCA.Metabolic profiling analysis of AAs in plasma from control, rAdLacZ and RCA groups were performed by gas chromatography-mass spectrometry as their ethoxycarbonylated, and tert-butyldimethylsilylated derivatives.When star symbol plotting was applied to the group mean values of AAs after normalization to the corresponding normal mean values, the resulting star patterns of the two infection groups were deformed and characteristic of each group.This method allowed rapid discrimination of viral infection groups from normal group.
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