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目的进一步探讨压迫或紧贴视神经垂体瘤伽玛刀的治疗效果。方法采用Leksell B型伽玛刀对83例有视神经压迫的垂体瘤进行治疗,应用MRIT1权重增强薄层扫描,Kula和GammaPlan5.31版系统执行曲线包裹设计和剂量规划。采用40%～80%等剂量曲线包裹肿瘤,中心剂量30～80Gy,平均44.3Gy,边缘剂量12～28Gy,平均18Gy。视通路的接受剂量低于10Gy。64例获得随访。结果偏盲和视力改善率为81.3%,激素异常分泌控制率为84%,肿瘤生长控制率为96%。结论伽玛刀对压迫或紧贴视神经的垂体瘤治疗有视神经减压作用,对部分患者尚有控制激素异常分泌的作用,可作为这类肿瘤的备选治疗方法。
Objective To further explore the oppression or close to the optic nerve pituitary tumor gamma knife treatment. Methods Eighty-three pituitary tumors with oppression of the optic nerve were treated with a Leksell Type B gamma knife. MRIT1 weight-enhanced thin-layer scanning was performed. Kula and GammaPlan version 5.31 was used to perform curvilinear package design and dose planning. Tumors were coated with isodose curves of 40% -80% with a median dose of 30-80 Gy, an average of 44.3 Gy and an edge dose of 12-28 Gy with an average of 18 Gy. Depending on the pathway to accept the dose of less than 10Gy. 64 cases were followed up. Results The hemianopia and visual acuity improvement rate was 81.3%, hormone abnormal secretion control rate was 84%, tumor growth control rate was 96%. Conclusion Gamma Knife has ophthalmic decompression effect on oppression or optic nerve pituitary tumor, and some patients have the role of controlling the abnormal secretion of hormones, which can be used as an alternative treatment for these tumors.