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目的：探讨综合护理干预对长期住院精神病患者伴发躯体疾病的影响。方法将200例长期住院精神病患者随机分为两组，每组100例，均予以常规护理，研究组在此基础上予以综合护理干预，观察3个月。于干预前后采用汉密顿焦虑量表与汉密顿抑郁量表评定患者的焦虑抑郁情绪，统计两组躯体疾病发生率及疾病转归情况。结果干预后研究组汉密顿焦虑量表、汉密顿抑郁量表评分及躯体疾病发病率、转院率、死亡率均显著低于对照组（P＜0．01）。结论对长期住院精神病患者采用综合护理干预，能有效缓解焦虑、抑郁症状，降低躯体疾病发生率。“,”Objective To explore the influence(CNI) of comprehensive nursing intervention on accompa‐nied somatic diseases of long‐term hospitalization psychotics .Methods A total of 200 long‐term hospitali‐zation psychotics were randomly assigned to two groups of 100 ones each ,both groups received routine nursing ,on this basis research group was plus comprehensive nursing intervention .Anxiety‐depression conditions were assessed with the Hamilton Anxiety Scale (HAM A ) and Hamilton Depression Scale (HAMD) before and after intervention ,patients’ somatic diseases and prognoses observed ,recorded ,and compared .Results The incidence of somatic disease was significantly lower in research than in control group (P< 0 .05 or 0 .01) ,after intervention the HAMA and HAMD scores of both groups lowered more significantly compared with pre‐intervention (P< 0 .01) ,so did those in research than in control group (P< 0 .01) ,transference to another hospital and death rate were respectively 3 .0% and 1 .0% in research and 19 .0% and 9 .0% in control group ,the former significantly lower than the latter (P< 0 .01) .Conclusion Comprehensive nursing intervention could preferably relieve anxious and depressive symptoms of long‐term hospitalization psychotics and reduce concurrency rate of somatic diseases .