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利用麻醉大鼠结扎冠状动脉前降支造成急性心肌梗塞及再灌注损伤模型,观察中药益气活血方对心肌缺血及再灌注时心律失常的作用。以益气活血方10ml/kg体重于冠状动脉结扎前灌胃3d,第4天分别行冠脉结扎及再灌注实验。结果表明益气活血方能显著降低急性心肌缺血及再灌注时心律失常的发生率及严重性。体外电子顺磁共振法测定表明,益气活血方能有效清除超氧阴离子自由基,这可能是其抗再灌注心律失常作用的机制之一。
The model of acute myocardial infarction and reperfusion injury caused by ligation of the anterior descending coronary artery in anesthetized rats was used to observe the effect of Yiqi Huoxue Decoction on arrhythmia during myocardial ischemia and reperfusion. The Yiqihuoxuefang 10ml/kg body weight was intragastrically administered for 3 days before coronary artery ligation, and coronary artery ligation and reperfusion experiment were performed on the 4th day. The results showed that Yiqi Huoxue can significantly reduce the incidence and severity of arrhythmia during acute myocardial ischemia and reperfusion. The in vitro electron paramagnetic resonance assay showed that Yiqi Huoxue can effectively remove superoxide anion free radicals, which may be one of the mechanisms of its anti-reperfusion arrhythmia effects.