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随着血管生成拟态(VM)这一概念的提出,相关的研究和报道逐渐引起关注。VM在肿瘤的发生、发展及转移、分化过程中起到重要的作用。近来抗肿瘤血管生成成为肿瘤治疗研究的一个热点,但这种治疗是否会导致肿瘤恶性程度增高,也颇具争议。本文旨在探讨目前有关VM形成的分子机制及相关功能研究,为VM靶向治疗肿瘤开发新药提供重要的参考价值。1 VM的发现VM是近年来发现的一种不依赖机体血管内皮细胞的全新肿瘤微循环模式,由PAS及IV型胶原阳性的基质包绕内皮样肿瘤细胞形成的管状网络,其内衬覆的肿瘤细胞可为实体细
With the introduction of the concept of VM (VM), relevant researches and reports have drawn more and more attention. VM plays an important role in tumorigenesis, development, metastasis and differentiation. Recently, anti-tumor angiogenesis has become a hot research topic in cancer treatment. However, it is controversial whether this treatment will lead to the increase of tumor malignancy. This article aims to explore the current molecular mechanism of VM formation and related functional studies for the VM targeted therapy to develop new drugs provide an important reference value. 1 VM Discovery VM is a novel tumor microcirculation pattern independent of body vascular endothelial cells in recent years. It is a tubular network of endothelial-like tumor cells surrounded by PAS and type IV collagen-positive matrices. Tumor cells can be solid