磷脂酰肌醇3-激酶(PI3-K)是一种与细胞信号转导有关的脂类第二信使。在人类肿瘤中,已发现PI3-K信号途径的各成员具有基因结构,蛋白质表达和激酶活性等的异常改变。PI3-K在卵巢癌中有异常表达,为肿瘤早期诊断、开发新的抗肿瘤药物和寻找新的基因治疗靶点提供了新的思路。 Phosphatidylinositol 3-kinase (PI3-K) is a lipid second messenger that is involved in cell signaling. In human tumors, each member of the PI3-K signaling pathway has been found to have abnormal changes in gene structure, protein expression and kinase activity. The abnormal expression of PI3-K in ovarian cancer provides a new idea for the early diagnosis of tumors, the development of new anti-tumor drugs and the search for new gene therapy targets.