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目的:观察小半夏加茯苓汤对小鼠的急性毒性实验和了解毒靶器官。方法:以最大浓度药液灌胃给药,24h内给药3次,连续观察7天。详细观察记录小鼠行为活动、状态、饮食、大便、小便、毛色、分泌物及死亡等情况。结果:全部动物健存,也无明显中毒反应,测得小半夏加茯苓汤最大受试药物量为267.60grawdrug·kg-1,为临床患者拟用量的382.29倍。结论:小半夏加茯苓汤对小鼠无明显急性毒性反应。
Objective: To observe the acute toxicity test of Xiao Ban Xia Ganying Decoction in mice and to understand the target organs. Methods: The maximum concentration of liquid gavage administration, administration within 24h within 3 times, continuous observation of 7 days. Detailed observation of mice behavioral activity, status, diet, stool, urine, hair color, secretions and death and so on. Results: All animals were healthy, no obvious toxic reaction, the measured Xiaobanxia plus Poria Decoction maximum amount of 267.60grawdrug · kg-1 drugs, 382.29 times the amount intended for clinical patients. Conclusion: Xiaobanxia plus Fuling decoction has no obvious acute toxicity to mice.