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目的 探讨癫痫患者智能状况与脑脊液γ -氨基丁酸 (CSF -GABA)含量的关系。方法 采用韦氏智力量表对 40例癫痫患者进行智商测定 ,应用高效液相色谱法 (HPLC)测定其CSF -GABA含量 ,并对影响癫痫患者智能的因素进行分析。结果 40例癫痫患者中总智商FIQ≤ 89者 14例 ,占 3 5 %。癫痫患者智能状况主要与CSF -GABA含量、文化程度、发作类型呈正相关 ,与患者年龄呈负相关。其中以CSF -GABA含量对VIQ、PIQ、FIQ影响作用明显 (P <0 0 1,P <0 0 5 )。且癫痫病人智能障碍组CSF -GABA含量明显低于智能正常组 (P <0 0 1)。结论 CSF -GABA含量在一定程度上能反映癫痫患者智能状况 ,为临床判断、预防及治疗癫痫患者智能障碍提供客观依据
Objective To investigate the relationship between intelligence status and CSF γ-aminobutyric acid (CSF-GABA) level in patients with epilepsy. Methods 40 patients with epilepsy were measured by using the Wechsler Intelligence Scale. The levels of CSF-GABA in the patients with epilepsy were determined by high performance liquid chromatography (HPLC), and the factors influencing the intelligence of patients with epilepsy were analyzed. Results Among the 40 patients with epilepsy, 14 had FIQ ≤ 89, accounting for 35%. The intelligence status of epilepsy patients was positively correlated with CSF-GABA content, education level and type of attack, and was negatively correlated with patient’s age. The effect of CSF-GABA on VIQ, PIQ and FIQ was significant (P <0.01, P <0.05). CSF-GABA levels in patients with epilepsy were significantly lower than those in the normal group (P <0.01). Conclusion CSF-GABA content can reflect the intelligence status of patients with epilepsy to a certain extent and provide an objective basis for clinical judgment, prevention and treatment of intellectual disorders in patients with epilepsy