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【目的】 探讨晚发性维生素K(VK)缺乏症的血钙水平及与维生素D(VD)缺乏症的相关性。 【方法】 临床确诊的晚发性VK缺乏症所致颅内出血 (病变组 ) 43例 ,正常对照组 2 4例 ,测定血清钙、磷和碱性磷酸酶 (AKP) ,结果进行统计学分析。 【结果】 病变组血清钙 (1.76± 0 .2 9)mmol/L ,磷 (1.70± 0 .3 6)mmol/L ,AKP(3 0 8.98± 79.64 )U/L。对照组血清钙 (2 .19± 0 .2 6)mmol/L ,磷 (1.98± 0 .2 9)mmol/L ,AKP(2 2 5 .88± 3 7.87)U/L。差异有非常显著性意义(P <0 .0 1。 【结论】 晚发性VK缺乏症血清钙、磷明显降低 ,AKP明显升高 ,提示存在VD缺乏 ,血钙降低的原因与同时缺乏VD有关 ;晚发性VK缺乏症患儿血钙降低到一定程度发生惊厥时 ,可诱发或加重其颅内出血。因此 ,治疗时应注意适当补充VD与钙剂
【Objective】 To investigate the relationship between serum calcium levels and vitamin D (VD) deficiency in late-onset vitamin K (VK) deficiency. 【Methods】 43 cases of intracranial hemorrhage (pathological group) and 24 cases of normal control group (clinically diagnosed late VK deficiency) were enrolled in this study. Serum calcium, phosphorus and alkaline phosphatase (AKP) were measured and the results were analyzed statistically. 【Results】 Serum Ca (1.76 ± 0.29) mmol / L, P (1.70 ± 0.36 mmol / L, AKP (30.98 ± 79.64) U / L) The control group serum calcium (2.19 ± 0.26) mmol / L, phosphorus (1.98 ± 0.29) mmol / L, AKP (225.888 ± 3 7.87) U / L. (P <0.01). 【Conclusion】 The levels of serum calcium and phosphorus in patients with late-onset VK deficiency were significantly lower and AKP was significantly higher, suggesting the presence of VD deficiency. The reason for the decreased serum calcium was associated with the lack of VD ; Late VK deficiency in children with decreased serum calcium to a certain extent, convulsions, can induce or aggravate intracranial hemorrhage. Therefore, the treatment should pay attention to the appropriate supplementation of VD and calcium