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目的探讨大肠癌患者术后应用康莱特对免疫功能的影响。方法８２例患者手术后按治疗措施不同随机分为单纯手术组、常规化疗组和康莱特组。手术前和术后３周抽静脉血测定并比较Ｔ细胞亚群（包括ＣＤ＋３、ＣＤ＋４、ＣＤ＋８及ＣＤ＋４／ＣＤ＋８）的值并将所有患者术前指标做为患者组同５４例健康对照组比较。结果患者组术前与对照组相比，ＣＤ＋３、ＣＤ＋４、ＣＤ＋４／ＣＤ＋８细胞数减少（Ｐ＜０．０１）而ＣＤ＋８细胞无显著性差异（Ｐ＞０．０５）。术后患者组上述指标均显著上升（Ｐ＜０．０１），且不同术后处理组升高程度不同，康莱特组的ＣＤ＋３、ＣＤ＋４、ＣＤ＋４／ＣＤ＋８较其余两组有显著差异。结论康莱特可显著改善大肠癌患者术后的Ｔ细胞亚群值并优于单纯手术和常规术后化疗法。
Objective To investigate the effect of KLT on the immune function in patients with colorectal cancer. Methods Eighty-two patients were randomly divided into surgery alone group, conventional chemotherapy group, and Kanglaite group according to different treatment measures. The venous blood was measured before surgery and 3 weeks after surgery. The value of T cell subpopulations (including CD+3, CD+4, CD+8, and CD+4/CD+8) was determined and all patients’ preoperative indicators were compared with 54 healthy controls. Results Compared with the control group, the number of CD+3, CD+4, and CD+4/CD+8 cells in the patient group decreased before surgery (P<0.01), while CD+8 cells had no significant difference (P>0.05). In the postoperative patient group, all of the above indicators increased significantly (P<0.01), and the postoperative treatment group showed different degrees of elevation. The CD+3, CD+4, and CD+4/CD+8 in the Kanglaite group were significantly different from those in the other two groups. Conclusion Kanglaite can significantly improve the T-cell subpopulation value of patients with colorectal cancer after surgery and conventional postoperative chemotherapy.