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于家兔肠系膜上动脉夹闭后立刻肠道内给予充氧的氟碳代血液(PFBS)10ml/kg或等量生理盐水(对照)。肠系膜上动脉夹闭45分钟后,对照组动物MAP进行性下降,血浆K~+浓度逐渐升高,4小时存活率25％,平均存活时间165分钟,病理检查肠粘膜广泛水肿,绒毛坏死脱落。PFBS组动物MAP维持平稳,实验结束平均为8.26kPa(62mmHg),明显高于对照4.67kPa(35mmHg),血浆K~+浓度基本正常,4小时存活率75％,平均存活时间227分钟,与对照组相比差异显著;肠粘膜结构基本完整。结果表明:在肠系膜上动脉夹闭休克中,肠道内给予PFBS可保护肠粘膜结构,减轻休克程度,提高动物存活率。
Oxyfused fluorocarbon blood (PFBS) 10 ml / kg or an equal volume of saline (control) was administered intraperitoneally immediately after clipping the superior mesenteric artery in rabbits. After 45 minutes of superior mesenteric artery occlusion, MAP in the control group decreased progressively, plasma K + concentration gradually increased, 4-hour survival rate was 25% and mean survival time was 165 minutes. Pathological examination extensive intestinal mucosa edema and villus necrosis. The MAP in the PFBS group remained stable with an average of 8.26 kPa (62 mmHg) at the end of the experiment, which was significantly higher than that of the control (4.67 kPa, 35 mmHg). The K + concentration in the plasma was almost normal with a 4-hour survival rate of 75% and an average survival time of 227 minutes The difference between the two groups was significant. The structure of intestinal mucosa was basically intact. The results showed that in the superior mesenteric artery clamping shock, the intestine administration of PFBS can protect the intestinal mucosa structure, reduce the degree of shock and improve animal survival.