目的　探讨米非司酮和孕酮对子宫内膜异位症 (内异症 )患者异位子宫内膜 (异位内膜 )与正常子宫内膜 (在位内膜 )白细胞介素 6 (IL 6 )分泌的影响。方法　采用酶联免疫吸附试验 (ELISA)方法 ,检测米非司酮浓度为 1× 10 -6mol/L(米非司酮 1组 )、1× 10 -4 mol/L(米非司酮 2组 ) ,和孕酮浓度为 1× 10 -7mol/L(孕酮 1组 )、1× 10 -5mol/L(孕酮 2组 )与体外培养的异位内膜细胞和在位内膜细胞上清液作用后的IL 6水平。结果　米非司酮可降低异位内膜细胞IL 6水平 ,米非司酮 1组和米非司酮 2组的IL 6分为 (1914 33± 799 2 8) μg/L和(990 2 5± 5 8 40 ) μg/L ,两组与空白组比较 (下同 ) ,差异有极显著性 (P <0 0 1)。孕酮也可降低异位内膜细胞IL 6水平 ,孕酮 1组和孕酮 2组的IL 6分为(2 5 75 89± 119 75 ) μg/L和 (1736 2 5± 75 0 89) μg/L(P <0 0 1)。米非司酮还可使在位内膜细胞IL 6水平降低 ,其中米非司酮 1组和米非司酮 2组分别为 (34 6 96± 2 4 32 ) μg/L和 (2 70 2 2± 36 15 ) μg/L(P <0 0 1)。孕酮对在位内膜细胞IL 6水平无明显影响 (P >0 0 5 )。结论　米非司酮和孕酮可抑制异位内膜和在位内膜细胞IL 6的分泌 Objective To investigate the effects of mifepristone and progesterone on endometriosis (ectopic endometrium) and normal endometrium (eutopic endometrium) in patients with endometriosis (endometriosis) 6) the impact of secretion. Methods The concentration of mifepristone was 1 × 10 -6 mol / L (group 1) and 1 × 10 -4 mol / L (group Mifepristone) was detected by enzyme linked immunosorbent assay (ELISA) ) And progesterone concentration of 1 × 10 -7 mol / L (progesterone group 1), 1 × 10 -5 mol / L (progesterone group 2) and in vitro ectopic endometrial cells and eutopic endometrial cells Serum IL 6 levels after action. Results Mifepristone could decrease the level of IL 6 in ectopic endometrial cells. The levels of IL 6 in mifepristone group 1 and mifepristone group 2 were (1914 33 ± 799 28) μg / L and (990 25) ± 5 8 40) μg / L, the difference between the two groups was significant (P <0.01) compared with the blank group (the same below). Progesterone also reduced IL-6 levels in ectopic endometrial cells. IL-6 levels in progesterone-1 and progesterone-2 groups were (25 75 89 ± 119 75) μg / L and (1736 25 ± 75 0 89) μg / L (P <0 0 1). Mifepristone also reduced IL 6 levels in eutopic endometrial cells, with (34 6 96 ± 2 4 32) μg / L and (2 70 2) for mifepristone group 1 and mifepristone group 2 2 ± 36 15) μg / L (P <0.01). Progesterone had no significant effect on IL 6 level in eutopic endometrium (P> 0.05). Conclusion Mifepristone and progesterone can inhibit the secretion of IL 6 in ectopic endometrium and eutopic endometrium