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目的：胚胎期股骨头骨骺发育过程中，生化改变起着重要的作用。通过测定不同胎龄股骨头骨骺中氨基多糖及钙的含量，了解其变化规律及相关性，并阐明其意义。方法：收集３５例胎龄在１６周至３６周的正常人工流产胎儿和非骨病死亡新生儿，对其股骨头骨骺中氨基己糖、己糖醛酸和钙的含量进行测定。结果：随着胎龄的增加，股骨头骨骺中氨基己糖和己糖醛酸的含量逐步下降，而同期钙的含量却逐步上升。在２４～２８周胎龄组这种变化趋势最明显。结论：氨基多糖的降解及随血管侵入所带来的钙盐是股骨头骨骺软骨钙化的前奏
OBJECTIVE: Biochemical changes play an important role in the development of embryonic femoral epiphysis. By measuring the content of aminopolysaccharides and calcium in epicarget of femoral head of different gestational age, understand its changing rule and correlation, and clarify its significance. Methods: Thirty-five normal abortion fetuses and non-newborn non-osteonecrosis fetuses from 16 weeks to 36 weeks old were collected. The contents of hexosamine, hexuronic acid and calcium in the femoral epiphysis were measured. Results: With the increase of gestational age, the contents of hexosamine and hexuronic acid in the epiphysis of femoral head gradually decreased, while the content of calcium increased gradually in the same period. In 24 to 28 weeks gestational age group this trend is the most obvious. CONCLUSIONS: Degradation of aminopolysaccharides and calcium salts associated with vascular invasion are the prelude to calcification of epiphyseal cartilage in the femoral head