睾丸素制剂,当口服给药时经门静脉循环吸收,在肝脏中大量经首过反应损失,并且有可能产生肝细胞毒性。而障碍性植入片(draw backs implants)和注射剂均令人无法接受,且疗效也不确定。使用舌下含服剂很难达到足够的血液水平。睾丸素的透皮制剂克服了上述制剂的一些不利因素。将睾丸素置于具有自身粘附作用的聚乙烯衍生聚合基质膜中,采用聚酯覆盖于表面,用时覆于阴囊上。此药膜对身体其他部位不产生升高血清睾丸素作用,故对部位具有专一性。而对于性机能低下的病人, Testosterone preparations, which are absorbed through the portal vein when administered orally, undergo large amounts of first-pass reaction losses in the liver and are likely to produce hepatotoxicity. Both draw back implants and injections are unacceptable and their efficacy is uncertain. It is difficult to achieve adequate blood levels with sublingual builders. Transdermal preparations of testosterone overcome some of the disadvantages of the above formulations. Testosterone was placed in a polyethylene-derived polymeric matrix membrane with its own adhesive effect, covered with polyester on the surface and over the scrotum. The film on the other parts of the body does not produce elevated serum testosterone, so the site is specific. For patients with low sexual function,