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糖尿病性肾小球硬化的实质是肾小球细胞外基质(ECM)的过度聚积。转化生长因子 β(TGF- β)对 ECM代谢起着重要的调节作用。有研究表明 ,肝素能抑制 ECM的生成 [1 ] 。为此我们运用免疫组化方法观察了糖尿病大鼠肾小球两种 ECM成分 ,层粘蛋白 (L N)、纤连蛋白 (FN )的表达与TGF-
The essence of diabetic glomerulosclerosis is excessive accumulation of glomerular extracellular matrix (ECM). Transforming growth factor beta (TGF-beta) plays an important regulatory role in ECM metabolism. Studies have shown that heparin can inhibit the formation of ECM [1]. To this end, we used immunohistochemistry to observe the expression of two glomerular ECM components, laminin (L N), fibronectin (FN) and TGF-