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目的:探究七氟烷和丙泊酚麻醉对老年肺癌患者的影响。方法:选取到我院就诊的160名老年肺癌患者作为实验对象,在征得患者及家属同意的情况下,自愿参与本次实验,将其随机分为两组,一组和二组,每组80名患者,在手术期间分别给予七氟烷和丙泊酚麻醉,手术结束后测量不同时间段内患者体内的S100β蛋白含量,对两组患者的情况进行详细的记录,以便对两组老年肺癌患者的治疗效果进行评价。结果:手术结束后两组老年肺癌患者在苏醒时间、神志恢复时间,手术拔管时间等方面比较有显著性差异(P<0.05),使用七氟烷进行麻醉的一组患者所需时间更短,体内的S100β蛋白含量低于使用丙泊酚麻醉的二组老年肺癌患者,MSSE评分在手术结束一小时后可以恢复在正常值附近,对患者认知能力和神经系统的影响较小。结论:说明七氟烷在老年肺癌患者的临床麻醉中使用效果优于丙泊酚,对老年患者的认知能力和神经系统伤害小,患者苏醒快,恢复时间短,体内的S100β蛋白含量低,适合在老年肺癌患者的临床治疗中进行应用。
Objective: To investigate the effects of sevoflurane and propofol anesthesia on elderly patients with lung cancer. Methods: A total of 160 elderly patients with lung cancer who were admitted to our hospital were selected as experimental subjects. Under the consent of patients and their families, volunteers were randomly assigned to two groups, one group and two groups. Each group Seventy-eight patients were anesthetized with sevoflurane and propofol respectively during the operation. After the surgery, the content of S100β protein in the patients was measured at different time points. The two groups of patients were recorded in detail in order to compare the two groups of elderly patients with lung cancer The patient’s treatment was evaluated. Results: There were significant differences in recovery time, recovery time and extubation time between two groups of elderly patients with lung cancer at the end of surgery (P <0.05). Patients in the group receiving sevoflurane anesthesia needed less time , The S100β protein content in vivo was lower than that of the two groups of elderly patients with lung cancer who were anesthetized with propofol. The MSSE score recovered to normal value one hour after the end of surgery and had little effect on cognitive ability and nervous system. CONCLUSIONS: Sevoflurane is superior to propofol in clinical anesthesia in elderly patients with lung cancer. It has lower cognitive ability and nervous system injury in elderly patients. The recovery of sevoflurane is faster, the recovery time is shorter, the content of S100β protein in the body is lower, Suitable for elderly patients with lung cancer clinical treatment applications.