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目前耐药绿脓杆茵感染的治疗仍是一个麻烦问题,特别对急性白血病、恶性淋巴肿瘤以及三度烧伤病人来说,常固耐药绿脓杆菌感染而危及生命,有些报导指出绿脓杆菌败血症的死亡率仍较高。 在各种抗生素中,对绿脓杆菌比较有效的有下面三种:(1)多粘菌素类的多粘菌素B(Polymyxin B)和粘杆菌素(Colistin);(2)青霉素类的羧苄青霉素(Carbenicillin)等半合成青霉素以及(3)氨基糖苷类的艮他霉素(Gentamicin)。一般认为理想的药物应具备对人体的毒副反应小而对致病菌有较强毒力的特点,人们把这种相对毒性称为药物的选择作用。
The current treatment of resistant Pseudomonas aeruginosa infection is still a troublesome problem, especially for patients with acute leukemia, malignant lymphoma and third degree burns, often resistant to life-threatening Pseudomonas aeruginosa infection and life-threatening, and some reports pointed out that Pseudomonas aeruginosa Sepsis mortality is still high. Among the various antibiotics, Pseudomonas aeruginosa is more effective in the following three categories: (1) Polymyxin B (Polymyxin B) and Colistin (Colistin); (2) Penicillins Semi-synthetic penicillins such as Carbenicillin, and (3) gentamicin of aminoglycosides. Generally believed that the ideal drug should have a small side effects on humans and pathogens have a strong virulence characteristics, people put this relative toxicity as the choice of drugs.