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综述离子敏感型即型凝胶的研究进展,包括其制剂特点、所用高分子辅料、制备工艺以及在眼部、鼻腔、口服等给药途径方面的应用情况。即型凝胶的溶液-凝胶转变性质,使其具有制备简单、使用方便、与用药部位尤其是粘膜组织亲和力强、滞留时间长等优点。重点综述离子敏感型即型凝胶的研究进展,对其制剂特点、所用高分子辅料、制备工艺以及在眼部、鼻腔、口服等给药途径方面的应用情况,并对该剂型目前存在的问题及其在中药中的应用做了展望。
This review summarizes the research progress of ion-sensitive, ie, gel-based gels, including the characteristics of their formulations, the use of polymeric excipients, their preparation techniques and their application in ophthalmic, nasal and oral administration. That is, the solution-gel transition properties of gelatin make it have the advantages of simple preparation, easy to use, strong affinity with medication sites, especially mucosal tissue, and long residence time. This review focuses on the research progress of ion-sensitive, ie, gel-like gels, the characteristics of their formulations, the use of polymeric excipients, their preparation techniques and their application in the ophthalmic, nasal and oral administrations and so on. And its application in traditional Chinese medicine made a prospect.